FAQ (Frequently Asked Questions)

  • Q: What is the success rate for IVA?
  • A: IVA is a new procedure and limited information on success rate is available at this time. IVA has only been tried in POI (primary ovarian insufficiency) patients. Of 27 POI patients in the initial trial, about 50% of them have residual follicles. Among those with follicles, 60% showed follicle growth, thus allowing the retrieval of mature oocytes for in vitro fertilization. It is estimated that a quarter of POI patients could generate mature oocytes. The final success for pregnancy among POI patients depends on patients' age. Older patients likely show lower success rate (see below). The first IVA baby boy was delivered Dec. 2013 and another IVA baby girl was delivered in 2014.
  • Q: Does the IVA procedure overcome age-related decline in egg quality?
  • A: No. Age-related increase in genetic abnormalities cannot be improved by IVA. IVA provides the possibility to generate many eggs and only one good egg is needed to derive a good embryo for pregnancy.
  • Q: I am 45 years old. What is the chance to get pregnant spontaneously?
  • A: Decrease in egg quantity, as well as quality, progresses exponentially after 35 years of age. Based on the 2008 report by Center for Disease Control (CDC) in the USA, the likelihood of conception per cycle for a woman at 40 and 45 years of age is approximately 10 and 1%, respectively.
  • Q: How do I know if IVA is suitable for me?
  • A: Talk to your Ob/Gyn doctor to seek consultation.
  • Q: Is IVA available outside of Japan?
  • A: The IVA procedure is relatively new and not practiced outside Japan. International IVA (iIVA) programs are being set up. Collaborating physicians throughout the world can refer patients to the IVA clinic in Japan. After ovary retrieval and IVA, patients can go back to their own local clinics for monitoring followed by IVF and embryo transfer. The estimated stay in Japan is one week. Please contact us regarding the availability of collaborating physicians in your country. Recently, the first pregnancy outside Japan was announced by Zhengzhou University Reproductive Medicine Center. Link
  • Q: I am 50 years old and in good health. I am anxious to have a baby. Can I try IVA?
  • A: Because IVA is a new procedure, only patients less than 46 years of age are recommended for this procedure. With improvement of the procedures, older patients might be accepted.
  • Q: I am not married but would like to have oocytes for future use. Shall I try IVA?
  • A: If you are young and have regular menstrual cycles, IVA is not the choice for fertility treatment. You can receive hormonal treatments to generate multiple eggs for storage and later use. If you are young but experiencing irregular cycles or amenorrhea, consult your Ob/Gyn physician for the possibility to store ovarian fragments for later use.
  • Q: I am not married but my preliminary diagnosis showed diminishing ovarian reserve. Should I try IVA?
  • A: Because oocyte quality and numbers go down with age, you can consider cryopreserve ovarian tissues for future IVA procedures.
  • Q: Is it possible to become pregnant without egg retrieval after IVA?
  • A: No. Because the location of the present graft is not optimal for egg(s) to travel to the Fallopian tubes, further modification of grafting site is needed for pregnancy without egg retrieval.